Ivabradine: A Sophisticated Approach To Heart Rate Modulation In Cardiovascular Pathologies.

• GEETA Y GUPTA,*  
• YOGESH A GUPTA

Abstract

Cardiac dysregulation, specifically perturbations in heart rate, constitutes a pivotal factor influencing the morbidity and mortality associated with diverse pathological conditions, including Angina (chronic/stable), Acute Coronary Syndrome, Heart Failure, Renal failure, Respiratory distress, Chronic Obstructive Pulmonary Disease, Multiorgan Dysfunction Syndrome, mitral valve prolapse, and mitral stenosis [1]. The pharmacological apparatus for heart rate control, refined over decades, encompasses various classes of agents, each adhering to specific protocols. Among these, Ivabradine, a relatively recent entrant into clinical practice, has garnered attention as a non-inferior alternative to extant heart rate-reducing medications, providing a subtle approach to cardiovascular therapeutics.

Keywords

Ivabradine, Funny (If) channel, Chronic stable angina, Acute coronary syndrome, Chronic heart failure, Multiorgan dysfunction syndrome, Cardiotonic drugs

Ahead of Print Date : 2023-12-09