A Novel In-Silico based drug Discovery of Neuroprotective Targets for Monosodium Glutamate

• Maharaja Dharmalingam,  
• Sowmiyadevi Suresh,  
• Venkatesh Gunasekaren*

Abstract

Monosodium glutamate (MSG) is a frequently used food additive that enhances flavour and is well-liked worldwide and has a significant interaction on nervous system. By using Chem Sketch or Chem Draw, Auto Dock Vina 4.2.6, BIOVIA Discovery Studio Visualizer, and neuroprotective targets of MSG with promising interactions with particular brain targets, we harness the computational power of molecular docking. In silico experiments had been used to screen for monosodium glutamate. Based on the docking interaction score and conventional hydrogen bond interactions, monosodium glutamate demonstrated maximal affinity towards a number of neuroprotective targets, including ionotropic NMDA 2A, metabotropic 4R, and metabotropic 1B. These three proteins interact powerfully with MSG. Despite the fact that the US FDA, FSSAI, WHO, and a number of other organizations advise an estimated safe dose of MSG, Certain adverse effects still have an impact on people. In future the dose reduction study can conduct to reduce the dose range to the particular dose for beneficial and neuroprotective effects by targeting these three proteins based on their docking interactions. For research on neuroprotection, these three targets are better choices. The identification of neuroprotective targets opens the door to more in vivo and invitro research on neuroprotective treatments.

Keywords

Monosodium Glutamate, Neuroprotection, NMDA2A, Metabotropic 4R, Metabotropic 1B,Docking