Targeting Cancer-Associated Fibroblasts - Are we there yet?

• Dilip Harindran Vallathol*

Abstract

Cancer cells rely on the surrounding environment to grow and spread. This environment contains structural components of which cancer associated fibroblasts play a major role in tumor cell growth, invasion, and metastasis. Cancer associated fibroblasts orchestrate the tumor microenvironment due to its plasticity. They also communicate with immune cells, aiding the cancer in evading immune detection. This communication is to give an overview of cancer associated fibroblasts and novel ways to target them.

Keywords

Cancer associated fibroblasts, tumor microenvironment