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- DOI 10.18231/j.ijpp.2024.029
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Ellagic acid: Exploring its potential in women healthcare
- Author Details:
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Pragya Pandey *
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Shoebul Haque
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Farah Asif
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Rakesh Kumar Dixit
Pragya Pandey *
Shoebul Haque
Farah Asif
Rakesh Kumar Dixit
The Potential of Ellagic Acid
Dear Editor,
I have read the article titled “Investigation of effect of ellagic acid on premature ovarian insufficiency” published in your journal. I want to congratulate the authors for this successful original research article and make my contributions to it.
Ellagic acid is a polyphenolic compound; chemically, it is a dilactone of hexahydroxy diphenic acid (HHDP). It is commonly found in fruits like pomegranates, raspberries, etc.[1]
Among its various properties are hypolipidemic and hypoglycemic actions. It is also found to decrease the occurrence of non-alcoholic fatty liver diseases.[2] Click or tap here to enter text. It also has shown an effect in preventing age-related disorders like dementia.[3]
Premature ovarian insufficiency or failure is a prevalent disorder in developed as well as developing nations. It is defined as non-physiological amenorrhea in females before the age of 40 but after puberty.
As rightly stated by the authors, ellagic acid has shown the potential to improve premature ovarian insufficiency. I would like to add that ellagic acid has been shown to have effects on hair follicle regeneration, as well as shown by previous studies.[4]
It is observed to show an effect on the stimulation of hair regeneration in animal models of ferroptosis. It has also shown improvement in testosterone-induced alopecia as well. Moreover, it has also shown improvement in the problem of graying of hair.[5]
Adding to the author's study, I wanted to convey that use of ellagic acid might also simultaneously aid in the hair loss associated disorders seen in patients of premature ovarian failure/insufficiency.
In conclusion, in a developing nation like ours, where healthcare is evolving at a rapid pace, having a single compound capable enough of addressing multiple associated disorders would be a boon. Premature ovarian failure itself, being a major load on women's healthcare, contributes to many associated disorders like anxiety and hair loss. In such a scenario, if proper research can be accumulated to address such issues simultaneously, it will play a major role in women's healthcare.
In the end, I would like to express my gratitude for allowing me to express my views on the related subject matter.
Conflict of Interest
None.
References
- G Derosa, P Maffioli, A Sahebkar. Ellagic acid and its role in chronic diseases. Adv Exp Med Biol 2016. [Google Scholar]
- J Sharifi -Rad, C Quispe, CM Castillo, R Caroca, MA Lazo-Vélez, H Antonyak. Ellagic acid: A review on its natural sources, chemical stability, and therapeutic potential. Oxid Med Cell Longev 2022. [Google Scholar]
- N Javaid, MA Shah, A Rasul, Z Chauhdary, U Saleem, H Khan. Neuroprotective effects of ellagic acid in Alzheimer's disease: focus on underlying molecular mechanisms of therapeutic potential. Curr Pharm Des 2021. [Google Scholar]
- H Fu, W Li, J Liu, Q Tang, Z Weng, L Zhu. Ellagic acid inhibits dihydrotestosterone-induced ferroptosis and promotes hair regeneration by activating the wnt/β-catenin signaling pathway. J Ethnopharmacol 2024. [Google Scholar]
- . Use of ellagic acid to treat gray hair. . [Google Scholar]