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Screening for anti-inflammatory and peripheral analgesic activity of Coleus amboinicus leaves using wistar albino rats

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Original Article

Author Details : Megha Rani N*, Prathima K Shetty, S N Rao, Roopa P Nayak

Volume : 7, Issue : 3, Year : 2020

Article Page : 164-167

https://doi.org/10.18231/j.ijpp.2020.028

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Abstract

Context: We have abundant plant resources with many health benefits. Use of plant material for health
benefits will help in reduce the cost of drugs and also provide a substitute drug that is less expensive.
Coleus amboinicus is plant largely distributed in Dakshina kannada and is used for its medicinal properties
as household cure.
Aim: We planned to find out the anti-inflammatory and peripheral analgesic activity of Aqueous Extract of
leaves of Coleus amboinicus.
Settings and Design: Wistar albino rats were randomly selected and tests were performed by dividing the
animals into three groups- control, standard, test.
Materials and Methods: Aqueous extract of leaves of Coleus amboinicus was prepared using soxhlet
apparatus. The dose of leaf extract used was 500mg/kg.
Statistical Analysis: Data was analysed by applying one way ANOVA followed by Dunnets multiple
comparison test using Graphpad Instat.
Results: The results obtained were statistically significant. In Carragenan induced inflammation model
significant inhibition of inflammation was shown by the test drug at the end of 3 hrs and in Acetic acid
induced writing test significant inhibition of occurrence of writhes was noted by the test drug.
Conclusion: This study validates the folkloric use of aqueous extract of leaves of Coleus amboinicus
(AECA) at the dose of 500mg/kg for its anti-inflammatory and peripheral analgesic activity.

Keywords: Coleus amboinicus, Aqueous extract, Antiinflammatory, Carragenan induced writhing test, Acetic acid induced writhing test.

How to cite : Megha Rani N, Shetty P K, Rao S N , Nayak R P , Screening for anti-inflammatory and peripheral analgesic activity of Coleus amboinicus leaves using wistar albino rats. Indian J Pharm Pharmacol 2020;7(3):164-167

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