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Hypoglycemic and antidiabetic evaluation of leaves of phyllanthus distichus in normal and alloxan induced diabetic rats

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Original Article

Author Details : Debashis Mohapatra*, Sunita Mishra

Volume : 7, Issue : 3, Year : 2020

Article Page : 189-202

https://doi.org/10.18231/j.ijpp.2020.032

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Abstract

The ethanolic extract of leaves of Phyllanthus distichus results maximum yield value than that of petroleum
ether extract, chloroform extract through successive extraction process. The ethanolic extract of leaves of
Phyllanthus distichus showed maximum control in blood sugar in hyperglycemic wistar rats than other
experimental extracts. The test extract also reduces the blood sugar level to a maximum extent in case
of normal animals. Among the study of effects of alcoholic extracts of leaves of Phyllanthus distichus
in both normoglycemic and hyperglycemic model through oral route. Toxicological study revealed that
the alcoholic extracts Phyllanthus distichus leaves were safe and does not alter normal physiological and
behavioral effect even at a higher dose level of 3000 mg/kg body weight.
Administration of alcoholic extracts Phyllanthus distichus significantly reduces the elevated glucose level
in alloxan induced diabetic rats confirms its anti-diabetic activity. This also reduces normal glucose level,
which reveals the hypoglycemic property. The whole protein, whole cholesterol, ASAT, ALAT, ALP
enzyme activity of alloxan administered rats showed significantly higher than normal rats, the test extract
treated rats significantly reduced the elevated levels. The results of the present investigation indicate that
the alcoholic extracts Phyllanthus Distichus leaves may have a place in the therapy of Diabetes Mellitus as
anti-diabetic and/or hypoglycemic agent. The hypoglycemic and/or anti-diabetic effect of the test extract
may be due to the influence on glycogenesis, glycogenolysis metabolic activity property of one or more
of its constituents. Ethanolic extract of leaves of Phyllanthus Distichus is beneficial in lowering the blood
sugar concentration and in the management of other diabetic complications without any doubt.

Keywords: Alcoholic Extract of Phyllanthus Distichus (AEPD), Antigen (Ag), Alanine Amino Transferase (ALAT)
Alkaline Phosphate (ALP), Asparatate Aminotransferase (ASAT), Aqueous (Aq), Body Wt, Direct Bilirubin (DB)
Diabetes Mellitus (DM), Phyllanthus Distichus (PD)

How to cite : Mohapatra D, Mishra S, Hypoglycemic and antidiabetic evaluation of leaves of phyllanthus distichus in normal and alloxan induced diabetic rats. Indian J Pharm Pharmacol 2020;7(3):189-202

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