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The anxiolytic action of alcoholic excerpt of Withania coagulans fruits in Swiss albino mice by Elevated Plus Maze

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Original Article

Author Details : Amit S Kamdi*, Devesh D Gosavi, Suvarna M Kalambe, Pankaj N Bohra

Volume : 7, Issue : 3, Year : 2020

Article Page : 203-209

https://doi.org/10.18231/j.ijpp.2020.033

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Abstract

Background: The various antianxiety drugs currently used cause numerous adverse drug reactions. Though
in the late seventies some work was done on Withania coagulans, it is the vulnerable species not found
plentiful. Therefore, it was worthy to investigate the anxiolytic actions of alcoholic extract of Withania
coagulans fruits in Swiss albino mice by using Elevated Plus Maze (EPM) test.
Aim: To study the antianxiety activity of alcoholic extract of Withania coagulans fruits in Swiss albino
mice by Elevated Plus Maze (EPM) test.
Materials and Methods: The antianxiety activity was measured using Elevated Plus Maze (EPM) test.
The antianxiety drugs promote the mice to spend more time in open arm and less time in close arm. This
increase in the time spent in the open space as well as number of entries from close to open space was
correlated statistically with control and standard in the EPM test.
Statistical Analysis: One way ANOVA was used for the statistical analysis.
Results: Time spent in the open arm (Open) as well as number of entries into the open arm (EOA) by
the Swiss albino mice was statistically highly significantly (p-value < 0> extract of Withania coagulans fruits in Elevated Plus Maze (EPM) test.
Conclusion: The alcoholic extract ofWithania coagulans fruits established the antianxiety activity in Swiss
albino mice by Elevated Plus Maze (EPM) test.

Keywords: Antianxiety, Elevated Plus Maze (EPM), Swiss albino mice (SAM), Withania coagulans.

How to cite : Kamdi A S, Gosavi D D, Kalambe S M, Bohra P N, The anxiolytic action of alcoholic excerpt of Withania coagulans fruits in Swiss albino mice by Elevated Plus Maze. Indian J Pharm Pharmacol 2020;7(3):203-209

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