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Vitamin D acts as independently from glucocorticoid receptor in animal model of asthma

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Original Article

Author Details : Ashok Agrawal*, Anita Mehta

Volume : 8, Issue : 1, Year : 2021

Article Page : 74-77

https://doi.org/10.18231/j.ijpp.2021.012

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Abstract

Now a day most of the patients on long term therapy of glucocorticoid become insensitive to corticosteroids and addition of vitamin D to such patients may enhance to response to corticosteroids. Therefore, we investigated anti-inflammatory activity of vitamin D in presence of glucocorticoids receptor antagonist; mifepristone, to assess whether, vitamin D acts as dependent or independently from glucocorticoids receptor. Wistar albino rats were sensitized with ovalbumin (OVA) and, upon OVA challenge, developed
airway eosinophilia and neutrophilia. Administration of dextamethasone, vitamin D and combination of dextamethasone+vitamin D, and dextamethasone+vitamin D+mifepristone significantly (P<0>

Keywords: Asthma, Vitamin D, Mifepristone.

How to cite : Agrawal A , Mehta A , Vitamin D acts as independently from glucocorticoid receptor in animal model of asthma. Indian J Pharm Pharmacol 2021;8(1):74-77

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