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Evaluation of anti-inflammatory effect of omega 3 polyunsaturated fatty acid in Guinea pigs

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Original Article

Author Details : Prabhat Ghatate, Neeraj Sadiq*, Usha Shree, Syeda Ayesha Fatima, P Raghunath Rao, Narsimha Rao Netha, Bhumesh Kumar

Volume : 8, Issue : 2, Year : 2021

Article Page : 136-140

https://doi.org/10.18231/j.ijpp.2021.021

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Abstract

Background: We need drugs to decrease inflammation as well as have very less side effects. Review of literature mentioned anti-inflammatory action of Omega 3 fatty acids. Hence, we selected this drug.
Aim: Our aim was to find the anti-inflammatory effect of Omega 3 fatty acid using animal model.
Study Design: The study is objective animal study where measurement of inflammation was done by observational methodology, for the present study four groups were made- 6 Guinea pigs in each group.
Control guinea pigs were fed distilled water, second group standard drug indomethacin 4mg/ kg body wt, test group 1 received 1200mg/kg body wt, test group II received 2400mg/kg body wt of Omega 3 fatty acid. All drugs given orally 30 minutes before exposure to UV radiation of 30 seconds duration was given and inflammation was observed at 6, 12 and 24 hrs after UV exposure in the form of scoring. Statistical significance was calculated using Anova method. For statistical analysis we have used SPSS
system version 20.
Results: Inflammation was observed in all the four groups of Guinea pigs, there was significant antiinflammatory
effect of omega 3 fatty acid in the dose of 1200mg/kg body wt and 2400mg/kg body wt at 12 and 24 hours.
Conclusions: Omega 3 fatty acids 1200mg/kg body wt orally produced significant anti-inflammatory effect against UV radiation induced inflammation in Guinea pigs at 12 and 24 hrs. However, standard drug could produce significant anti-inflammatory effect only at 24 hrs in comparison to control group. The anti-inflammatory effects of test 1, test 2 groups and standard group are comparable.

Keywords: Inflammation, Omega 3 fatty acid, UV radiation.

How to cite : Ghatate P , Sadiq N , Shree U , Fatima S A , Rao P R , Netha N R , Kumar B , Evaluation of anti-inflammatory effect of omega 3 polyunsaturated fatty acid in Guinea pigs. Indian J Pharm Pharmacol 2021;8(2):136-140

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