---

study of antiradical activity, phospholipase A and 15-lipoxygenase inhibitory activity of eight malian medicinal plants used by traditional healers to treat inflammatory diseases

---

Original Article

Author Details : BALLO Mahamadou N. H*, Youl Estelle N.H , Traore Karim, Diakite A.S Seidina, Diakite Mamadou, Ouedraogo Moussa, Sanogo Rokia, Bah Sekou

Volume : 9, Issue : 3, Year : 2022

Article Page : 174-179

https://doi.org/10.18231/j.ijpp.2022.031

Suggest article by email

Get Permission

---

Abstract

Pro-inflammatory enzymes play a key role in inflammatory processes and are potential targets of anti-inflammatory drugs. In this study, the objective was to evaluate the antiradical activity of the extracts and their ability to inhibit phospholipase A and 15-lipoxygenase activity. The hydroethanolic extract of revealed the strongest reducing power with an IC of 7.29 ± 0.61 µg/mL. The three most active extracts on PLA were hydroethanolic extracts of (IC of 21.43 ± 0.66 ?g/mL), (IC of 23.72 ± 0.71 µg/mL), (IC of 24.49 ± 0.39 µg/mL). The best inhibitory activity on 15-lipoxigenase was obtained with aqueous and hydroethanolic extracts of with IC of 18.35 ± 1.26; 18.47 ± 1.12 µg/mL respectively. The present study showed that extracts of leaves of and roots of have antioxidant activity and effectively inhibit sPLA, and 15-LOX pro-inflammatory enzymes

Keywords: Phospholipase A2, Ximenia americana, Terminalia macroptera, Cochlospermum tinctorium, Ximenia americana, 15-lipoxygenase, ABTS, Mali.

How to cite : Ballo Mahamadou N. H, N.h Y E, Karim T, Seidina D A , Mamadou D , Moussa O, Rokia S, Sekou B, study of antiradical activity, phospholipase A and 15-lipoxygenase inhibitory activity of eight malian medicinal plants used by traditional healers to treat inflammatory diseases. Indian J Pharm Pharmacol 2022;9(3):174-179

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.