---

Evaluation of antidepressant properties of ethanolic extract of root of Rubia cordifolia in Swiss albino mice

---

Original Article

Author Details : Ramesh Kumar Karri, Roopa P Nayak*

Volume : 9, Issue : 4, Year : 2022

Article Page : 231-235

https://doi.org/10.18231/j.ijpp.2022.042

Suggest article by email

Get Permission

---

Abstract

Background: Mental health has always been given a prime importance along with physical health by the World Health Organization (WHO). Depression contributes to significant disease burden at global level and is ranked by WHO as the single largest contributor to global disability. Oxidative stress plays an important role in the pathogenesis of many neurological conditions such as depression. is known to possess antioxidant properties; hence, this study has been conducted to evaluate the antidepressant activity of Rubia cordifolia root extract in rodent models.
Materials and Methods: Ethanolic extract of root powder (EERC) was used for evaluating the antidepressant activity in Swiss albino mice. EERC was used in two doses – 50 mg/kg and 100 mg/kg. Antidepressant activity was evaluated by performing Forced swim test and Tail suspension test with Imipramine (10mg/kg) as the standard drug. The data was analyzed using one way ANOVA (analysis of variance) followed by Tukey Krammer test. P value <0> Results: Forced swim test and tail suspension test showed significant decrease in the period of immobility by EERC treated groups indicating its antidepressant property. There is no significant difference observed between the two doses of the extract i.e.; 50 mg/kg and 100 mg/kg (inter-group comparison). The period of immobility and period of mobility were not significantly different from the standard group.
Conclusion: This study shows that ethanolic extract of root powder possess significant antidepressant properties. However, this is just a preliminary study. Further studies have to be carried out to find out the exact mechanism responsible for antidepressant activity by isolating the active constituents and performing neurotransmitter studies.

Keywords: Depression, Rubia cordifolia, Swiss albino mice, Antidepressants

How to cite : Karri R K, Nayak R P, Evaluation of antidepressant properties of ethanolic extract of root of Rubia cordifolia in Swiss albino mice. Indian J Pharm Pharmacol 2022;9(4):231-235

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.