Indian Journal of Pharmacy and Pharmacology
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2393-9079
Online ISSN: 2393-9087
CODEN : IJPPTK
Indian Journal of Pharmacy and Pharmacology (IJPP) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award programs. With more...Short Communication
Author Details :
Volume : 9, Issue : 4, Year : 2022
Article Page : 252-256
https://doi.org/10.18231/j.ijpp.2022.046
Abstract
Background: Even when there is enough oxygen available, cancer cells meet their energy requirements by increasing glucose intake, glycolysis rate, and lactate generation. Otto Warburg proposed this process, which is known as the Warburg effect. A recent method of drug discovery includes developing medications that interfere with glucose consumption and aerobic glycolysis, or lactate production in cancer cells. Curcumin (C), Quercetin (Q), Ellagic acid (E), and Resveratrol (R) were examined in U87 cells for their ability to induce cytotoxicity at certain concencentrtions, as well as modulate lactate-pyruvate metabolism.
Results: All the tested compounds and their combinations such as C+E, C+Q, C+R and Q+R have exhibited, dose-dependent cytotoxic effect against U87 Glioma cells. Besides, the compounds and their the combination (except ellagic acid) have modulated glucose intake, lactate-pyruvate, and NADH/NAD ratio in U87 Glioma cells.
Conclusions: Phytocompounds those modulate cellular metabolism in cancer cells are currently unknown. Our findings imply that the phytocompounds used in the study are involved in cancer cell metabolic reprogramming and have cytotoxic properties. These substances could be used for prevention and treating cancer.
Keywords: U87 cells, Glioma, Warburg effect, Lactate-pyruvate
How to cite : Sahoo A, Debata P R, Phytocompounds curcumin, quercetin, and resveratrol modulate lactate pyruvate level in U87 glioma cells. Indian J Pharm Pharmacol 2022;9(4):252-256
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