Print ISSN: 2393-9079
Online ISSN: 2393-9087
CODEN : IJPPTK
Indian Journal of Pharmacy and Pharmacology (IJPP) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award programs. With more...Original Article
Author Details :
Volume : 10, Issue : 3, Year : 2023
Article Page : 177-182
https://doi.org/10.18231/j.ijpp.2023.034
Abstract
This study was carried out to assess the in vitro dissolution of Butaproxyvon Capsule (Paracetamol 325mg and Diclofenac 50mg) by calculating the percentage mean drug dissolved and disintegration time, as well as acid neutralizing time.
The capsules were tested using three different types of dissolution medium, including pH6.8 phosphate buffer, pH7.5 phosphate buffer, and pH4.5 acetate buffer. The disintegration apparatus was used to calculate the disintegration time, and the acid neutralizing capacity was determined by titrating the capsule content mix with hydrochloric acid with 0.5N sodium hydroxide.
Acid neutralizing capacity was found 12.33 mEq/g. Disintegration time was found in the range of 4.40 to 10.00 minutes. % Mean Paracetamol release was found to be almost similar after 60 minutes in all media. % Mean Diclofenac Potassium release was to be found almost similar after 60 minutes by using pH 6.8 and pH 7.5 phosphate media.
% Mean drug released for Diclofenac Potassium was found 13% in 4.5 Acetate media, and the released pattern was not uniform. This may be attributed to the low solubility of Diclofenac potassium in 4.5 Acetate media.
Keywords: Paracetamol, Diclofenac, Dissolution study, Disintegration time, Acid Neutralizing Capacity, Solubility
How to cite : Dhore M, Muchhala S, Panigrahi D, Bhagat S, Rathod R, Kotak B, Assessment of dissolution, disintegration time, and acid-neutralizing capacity of Butaproxyvon capsules (Paracetamol 325mg and diclofenac potassium 50mg). Indian J Pharm Pharmacol 2023;10(3):177-182
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