Indian Journal of Pharmacy and Pharmacology
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2393-9079
Online ISSN: 2393-9087
CODEN : IJPPTK
Indian Journal of Pharmacy and Pharmacology (IJPP) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award programs. With more...Original Article
Author Details :
Volume : 11, Issue : 1, Year : 2024
Article Page : 29-37
https://doi.org/10.18231/j.ijpp.2024.006
Abstract
Background: One common medical condition affecting the reproductive system in older women is premature ovarian failure (POF). POF can result from radiation therapy, chemotherapy, immune system problems, infection, inflammation, and genetic mutation.
Aim: The current study examined the effect of Ellagic acid on Premature Ovarian Insufficiency.
The study utilized, 8-12 months old 150 ± 20 gm, 42 female wistar rats. For the induction of Premature Ovarian Insufficiency, Tripterygium Glycoside (TG) was administered at a dosage of 50 mg/ml dissolved in water for injection once daily. Clomiphene Citrate, 1 mg/kg was administered orally once daily for 21 days. Ellagic acid was given orally once daily at concentration of 10 mg/kg, 20 mg/kg, 30 mg/kg. The statistic of the data was determined by using ANOVA test.
Results: The results showed that effect of Ellagic acid on premature ovarian insufficiency as evidenced by decreased levels of cholesterol, triglycerides, follicle stimulating hormone and Luteinizing hormone and increased levels of estrogen.
Conclusions: According to the current study, female wistar rats with Tripterygium Glycoside induced Premature Ovarian Insufficiency can benefit from treatment with an Ellagic acid.
Keywords: Ellagic acid, Premature Ovarian Insufficiency, Tripterygium Glycoside, Clomiphene Citrate, ANOVA
How to cite : Sarode V V, Gautam S P, Investigation of effect of ellagic acid on premature ovarian insufficiency. Indian J Pharm Pharmacol 2024;11(1):29-37
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