Indian Journal of Pharmacy and Pharmacology
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2393-9079
Online ISSN: 2393-9087
CODEN : IJPPTK
Indian Journal of Pharmacy and Pharmacology (IJPP) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award programs. With more...Review Article
Author Details :
Volume : 11, Issue : 4, Year : 2024
Article Page : 178-184
https://doi.org/10.18231/j.ijpp.2024.031
Abstract
Warfarin, a widely used oral anticoagulant and vitamin K antagonist, plays a critical role in the prevention and treatment of venous thrombosis and thromboembolic complications. This review explores the pharmacological properties, pharmacokinetics, pharmacodynamics, therapeutic monitoring, and drug-food interactions of warfarin. By inhibiting vitamin K-dependent clotting factors, warfarin induces a controlled anticoagulation state. However, its narrow therapeutic index presents challenges in achieving and maintaining optimal dosing. Regular monitoring of the International Normalized Ratio (INR) is essential to ensure efficacy while minimizing risks. Warfarin's pharmacokinetics, characterized by its racemic mixture and metabolism, contribute to its sensitivity to drug-drug and drug-food interactions. These interactions often necessitate personalized dosing and close monitoring. This review emphasizes evidence-based strategies for warfarin management, including the application of nomogram, computer-assisted dosing systems, and protocols for handling adverse events. It underscores the importance of balancing therapeutic benefits with safety to optimize outcomes for patients undergoing warfarin therapy.
Keywords: Warfarin, Vitamin K antagonist, International Normalized Ration (INR), Warfarin therapy, Clotting factors
How to cite : Oommen B M, Umashankar N, The role of warfarin in anticoagulation therapy: Current insight’s and clinical perspectives. Indian J Pharm Pharmacol 2024;11(4):178-184
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