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The natural flavone quercetin: An extensive analysis of its pharmacological mechanisms and medicinal prospects

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Review Article

Author Details : Kalyani Thombre, Krishna Radheshyam Gupta*, Sudhanshu Sukhdeve, Pavan Sakharwade, Aparna Raut, Amaanullah Siddiqui, Mimind Umekar

Volume : 11, Issue : 4, Year : 2024

Article Page : 185-194

https://doi.org/10.18231/j.ijpp.2024.032

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Abstract

Natural flavonoid quercetin is widely distributed in fruits, vegetables, and medicinal plants. It has attracted much interest due to its wide range of biological advantages and potential as a treatment for several illnesses. To better understand the mechanisms behind the therapeutic of effects quercetin in cancer, obesity, diabetes, and osteoporosis, this review attempts to present a thorough overview of these mechanisms. By promoting osteoblast differentiation, reducing osteoclast activity, and increasing bone mineral density, quercetin shows promise as a protective agent against bone loss in osteoporosis. Its anti-inflammatory properties also help to reduce the risk of fracture and bone resorption linked to osteoporosis. Through its targeting of various signalling pathways involved in cell proliferation, apoptosis, angiogenesis, and metastasis, quercetin shows promising anti-cancer properties in cancer. Moreover, its effectiveness in reducing the progression of cancer is attributed to its capacity to regulate inflammation and oxidative stress. Through its effects on adipocyte differentiation, glucose uptake, insulin signalling, and lipid metabolism, quercetin shows anti-obesity and anti-diabetic effects in obesity and diabetes. Furthermore, the antioxidant and anti-inflammatory qualities of quercetin are essential in reducing the negative effects of obesity on insulin resistance and the complications associated with diabetes. In summary, this review offers valuable implications for the development of quercetin-based therapeutics and nutraceuticals for disease management by shedding light on the complex mechanisms through which quercetin exerts its biological benefits in different disease contexts.

Keywords: Flavone, Quercetin, Anticancer, Osteoporosis, Inflammation, Obesity

How to cite : Thombre K, Gupta K R, Sukhdeve S, Sakharwade P, Raut A, Siddiqui A, Umekar M, The natural flavone quercetin: An extensive analysis of its pharmacological mechanisms and medicinal prospects. Indian J Pharm Pharmacol 2024;11(4):185-194

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