Indian Journal of Pharmacy and Pharmacology
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2393-9079
Online ISSN: 2393-9087
CODEN : IJPPTK
Indian Journal of Pharmacy and Pharmacology (IJPP) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award programs. With more...Review Article
Author Details :
Volume : 2, Issue : 1, Year : 2015
Article Page : 27-42
Abstract
The objective of the present investigation is to prepare and evaluate the controlled release matrix tablets of a water soluble drug (ropinirole hydrochloride) using direct compression and Wet granulation technology. Ropinirole Hydrochloride is a hydrophilic drug and has pH independent solubility. It is used in the treatment of idiopathic parkinsonsdisease. The controlled release matrix tablets of ropinirole hydrochloride were prepared using various polymers: guargum, sodium alginate and carbopol 940P.The matrix tablets were prepared using two strategies: direct compression and wet granulation. The tablets were evaluated for the various quality control parameters and the drug release was evaluated in pH 1.2 and in pH 7.4 buffer. The optimized formulation containing drug and guar gum controlled the drug release up to 8 hours. The drug release from the optimized formulation (drug: guar gum,1:2.5) followed first order kinetics and showed non-fickian diffusion mechanism. The FTIR studies indicated the lack of drug-polymer interaction. The formulated controlled release tablets can decrease the frequency of drug administration, decrease the plasma drug fluctuation and it can improve the patient compliance.
Key words: Ropinirole Hydrochloride, Controlled release, matrix tablets
How to cite : Varma M M, Kumar A M S, FORMULATION AND EVALUATION OF MATRIX TABLETS OF ROPINIROLE HYDROCHLORIDE FOR ORAL CONTROLLED RELEASE. Indian J Pharm Pharmacol 2015;2(1):27-42
This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
