Indian Journal of Pharmacy and Pharmacology
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2393-9079
Online ISSN: 2393-9087
CODEN : IJPPTK
Indian Journal of Pharmacy and Pharmacology (IJPP) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award programs. With more...Original Article
Author Details :
Volume : 4, Issue : 3, Year : 2017
Article Page : 147-152
Abstract
Introduction: The introduction of Highly Active Anti-retroviral Therapy (HAART) has led to significant reduction in AIDS related morbidity & mortality. The majority of drugs available today are costly & have serious adverse effects, undesirable drug interactions & have to be taken lifelong. Though Anti-retroviral Therapy (ART) has increased lifespan of HIV positive patients, adverse drug reactions (ADRs) of this therapy still remains a major concern.
Objective: To collect demographic details & to assess incidence & causality of ADRs in HIV positive patients receiving ART.
Materials and Method: A retrospective observational study was carried out for a period of 18 months (1st January 2014 to 30th June 2015) at Government Medical College & Hospital, Nagpur. The ADRs reported by physician were collected, analysed & causality assessment was done.
Result: Out of 85 patients evaluated, 58 (68.3%) were females. ADRs reported were rash (40.6%), anemia (26.0%), nausea (16.7%), dizziness (6.3%), vomiting (5.2%), gastritis (3.2%), Steven Johnson Syndrome (1.0%) & diarrhoea (1.0%). Out of 96 ADRs reported, 39 (40.6%) were related to skin. Use of Zidovudine + Lamivudine + Nevirapine regimen reported majority of ADRs. Sixty one (67%) regimens were dechallenged, 29 (31.9%) regimens were continued while only 1 (1.1%) regimen was rechallenged. Seventy six (79.2%) ADRs were probable & 1 (1.0%) was definite as assessed by Naranjo’s Causality Assessment Scale.
Conclusion: Rash was commonly reported ADR from ART. The findings from study suggests that there is need for intensive monitoring of ADRs in ART centre of Government Medical College & Hospital (GMCH), Nagpur.
Keywords: Anti-retroviral Therapy (ART), Adverse Drug Reactions (ADRs), Retrospective Observational Study, Causality assessment, Central India
How to cite : Sharma V S, Motghare V M, Dakhale G N, Pimpalkhate S A, Bajait C S, A retrospective study to determine adverse effects of anti-retroviral agents in tertiary care hospital in Central India. Indian J Pharm Pharmacol 2017;4(3):147-152
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