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Optimization and study of variables in microwave assisted organic synthesis of some biologically active chalcones

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Original Article

Author Details : R.R. Somani, Devendra Madan, Pratik Barve, Rewa Badve

Volume : 4, Issue : 3, Year : 2017

Article Page : 153-160

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Abstract

Chalcones are ?,β-unsaturated ketone compounds, constituting an important class of natural products belonging to the flavonoid family. They have been reported to possess a wide spectrum of biological activities, including anti-bacterial, anti-inflammatory, anti- tumor, anti-malarial, anti-fungal and anti-viral etc. Thus, synthesis of Chalcones has generated great interest among organic as well as medicinal chemists. This synthesis can be achieved by conventional methods or by Greener methods, like Microwave assisted organic synthesis (MAOS). Advantages of microwave synthesis over conventional synthesis include energy efficient reactions, less consumption of time to complete the reaction and improved yields. The conventional technique for any organic synthesis suffers from several pitfalls such as utilization of more time, energy and efforts, wastage of solvents and reactants and compromised yields. These inconsistencies can be overcome by the use of optimization techniques. Optimization techniques require lesser experiments to achieve an optimum result, yields “best” solution in presence of competing objectives, makes problem tracing and rectification quite easy. Optimization techniques encompass experimental design, mathematical models and graphical outcomes. With this background, in present work, eight Chalcones were synthesized using Microwaves. The synthetic procedure was optimized using 3² Factorial design as the statistical technique. Yield and time required to complete reaction were considered as response factors. The validation of optimized solutions was also performed.

Keywords: Chalcones, Factorial design, MAOS, Optimization, Green Chemistry

How to cite : Somani R, Madan D, Barve P, Badve R, Optimization and study of variables in microwave assisted organic synthesis of some biologically active chalcones. Indian J Pharm Pharmacol 2017;4(3):153-160

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