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Adverse drug reactions in patients on aspirin therapy with concomitant antihypertensive medication in a tertiary care hospital of deccan plateau

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Original Article

Author Details : Tamilisetti Vidya Sagar, Sanjay Kumar, Pramila Nayak

Volume : 5, Issue : 2, Year : 2018

Article Page : 71-74

https://doi.org/10.18231/2393-9087.2018.0016

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Abstract

Introduction: To know adverse drug reactions when Aspirin is prescribed with Antihypertensive medications.
Materials and Methods:Prospective observational study conducted in a tertiary care hospital, total 60 patients of age Casuality assessment of all ADRs was done by Naranjo ADR scalegroup 18 to 65 years were included in the study, It is a 12 week study, clinical examination done at enrollment and with subsequent follow up at 4,8 and 12 weeks,Base line investigations done at enrollment and at 12 weeks ,ADR monitoring done at each follow up
Results:Out of 45 patients who experienced adverse effects, causality assessment shows that Aspirin is responsible for producing ADRs in 15 patients and in Betablocker therapy and 26% in Aspirin with thiazide diuretics and 16% in aspirin with ACE inhibitors or Calcium channel blockersremaining 30 patients, Aspirin interaction is likely cause for ADRs, Incidence of adverse effects is 40% in Aspirin with concomitant
Conclusion: This study shows Betablockers and Thiazide diuretics in treatment of hypertension,Incidence of ADRs is high in elderly patients,increased incidence of Adverse drug reactions (though these are mild ADRs) when Aspirin is added to Betablockers and Thiazide diuretics in treatment of hypertension,Incidence of ADRs is high in elderly patients.

Keywords:Aspirin, Betablockers, Calcium channel blockers, ACE inhibitors, Thiazide diuretics, Naranjo scale

How to cite : Sagar T V, Kumar S, Nayak P, Adverse drug reactions in patients on aspirin therapy with concomitant antihypertensive medication in a tertiary care hospital of deccan plateau. Indian J Pharm Pharmacol 2018;5(2):71-74

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