---

Method Development and Validation for the Estimation of Saroglitazar in Bulk and Pharmaceutical Dosage Form by RP-HPLC

---

Original Article

Author Details : Hanumantha Rao K, Lakshmana Rao A, Chandra Sekhar KB

Volume : 2, Issue : 3, Year : 2015

Article Page : 150-154

Suggest article by email

Get Permission

---

Abstract

A simple, rapid, precise and accurate RP-HPLC method was developed and validated for the determination of Saroglitazar in tablet dosage form. Separation of the drug was achieved on a Kromasil C18 Column (150 mm x 4.6 mm I.D., 5 µm particle size). The method showed a linear response in the concentration range of 10-60 ?g/ml using 0.1% orthophosphoric acid buffer: acetonitrile as the mobile phase in the ratio of 45:55 v/v with detection at 295 nm with a flow rate of 1 ml/min and retention time was 3.430 min. The method was validated as per the ICH guidelines. The method was successfully applied for routine quality control analysis of Saroglitazar in tablet dosage form.

Keywords: Saroglitazar, estimation, UV detection, dosage form.

How to cite : Hanumantha Rao K, Lakshmana Rao A, Chandra Sekhar Kb, Method Development and Validation for the Estimation of Saroglitazar in Bulk and Pharmaceutical Dosage Form by RP-HPLC. Indian J Pharm Pharmacol 2015;2(3):150-154

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.